Endocrine Abstracts

Introduction: Vitamin D deficiency is very common in our population.It is not clear which is the most effective vitamin D dosing regimen in patients with deficiency.Objective: To compare two vitamin D supplementation regimen in patients with vitamin D deficiency.Material and methods: This is an interventional study: Patients atended in our clinic during May and June 2017 with 25-Hydroxyvitamin D below 30 ng/ml were consecutively se...

This is a 38-year-old male, a regular user of a gym with the sole purpose of improving his physical performance and muscular strength and habitual consumer of hyperproteic dietary supplements. Among his PAs he denies toxic habits, and highlights the removal of the right testicle in childhood. Consultation for decreased desire and sexual potency, together with pain and turgor in the left breast; hair loss at the frontal level, in analytic carried out by the Primary Care Physici...

The KINGS mouse harbours a mutant Ins2 which drives beta cell ER stress, however only males develop diabetes. Since diabetes incidence is lower in women and ER stress is implicated in human diabetes, we investigated the influence of oestrogen and testosterone in mediating sex differences in the KINGS mouse. To investigate the influence oestrogen (E2) and testosterone removal on glycaemic control, male (n =4-6) and female (n =9) KINGS mice underwent p...

Background: We report a case of a patient with an ileocecal neuroendocrine tumor (NET) metastatic to both breasts, for whom the initial clinical presentation was chronic diarrhea Breast metastases were initially suspected by a 68-Gallium DOTANOC PET/CT and were confirmed by histopathology. We also performed a comprehensive (non-systematic) literature review through which we identified 116 cases of NENs metastatic to breast.Methods: Case report and compre...

Aims: We aimed to evaluate the relationship between glycosylated hemoglobin (HbA1c), time-in-range (TIR), Glucose Management Index (GMI) and coefficient of variation (CV) in a cohort of adult patients with type 1 diabetes (T1DM) and flash glucose monitoring (FGM).Material and methods: Cross-sectional study of patients with T1DM who FGM from Córdoba, Spain. Demographic and analytical data were collected. Glucose metrics and engagement statistics (adj...

Introduction: Primary adrenal carcinoma is a very rare pathology, its treatment is fundamentally surgical and adjuvant treatment with mitotane can prevent recurrences. The prognosis varies depending on the patient, the stage and the histopathological diagnosis. We present the case mix of patients diagnosed with adrenal cortex carcinoma in our center between 2012-2022 and review the management of this pathology.Patients and Methods: Retrospective study on...

Introduction: The regulation of glucose and lipid metabolism in the brain is essential to ensure overall neurological health and proper functioning. Increased glycolysis and lipogenesis, if not properly regulated, can potentially lead to an imbalance between energy production in the brain. Glucose and lipid metabolic dysregulation contribute to the development and progression of various brain diseases. Besides other factors maternal undernutrition may alter glucose and lipid m...

Introduction: In addition to physiological causes, the hyperprolactinemia spectrum includes iatrogenesis, pituitary adenomas, various diseases and functional disorders. Hyperprolactinemia accurate etiological diagnosis is essential for appropriate treatment. Non-functioning pituitary incidentalomas occur in approximately 10% of the population and tiny microprolactinomas could be elusive to imaging by magnetic resonance (MRI). Therefore, the coincidence of hyperprolactinemia an...

We present the case of a 41-year-old man with a history of testicular seminoma treated with surgery and chemotherapy, and post-chemotherapy chronic kidney disease. He was initially referred to Otolaryngology for a 1-month history of neck mass sensation, with associated dysphonia, dysphagia and dyspnea. On examination, thyroid gland was enlarged. Fibroscopy was performed in consultation, revealing paralysis of the left vocal cord. The patient was referred to Endocrinology and S...

Prostate cancer (PCa) is one the leading causes of cancer-related deaths among men in developed countries. Therefore, identification of novel molecular and therapeutic approaches to tackle this pathology are urgently needed. In this scenario, our group has recently reported that elements of the cellular machinery controlling alternative splicing processes might be used as potential novel therapeutic tools against PCa and castration-resistant PCa (CRPC). In this context, RBM22 ...